WebPTPN18 was up-regulated in endometrial cancer tissues and high level of PTPN18 promoted proliferation and metastasis of EC cells. Methods: The expression of PTPN18, GPX4 and xCT in endometrial cancer tissues and KLE cells was detected by immunohistochemistry and Western blot, respectively. Lentiviral transfection were used to silence PTPN18 ... Web8 hours ago · Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. ... The antioxidant enzyme GPX4, a selenocysteine-containing enzyme that blocks iron ...
NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ...
WebAug 23, 2024 · Several key ROS-related proteins such as glutathione peroxidase 4(GPX4) , ... At the same time, lymph node metastasis was more common in ESCC patients with low DNAJB6 levels than patients with high DNAJB6 levels . However, relevant studies are still insufficient, and the explicit mechanism of how DNAJB6 causes ferroptosis in cells … WebFeb 12, 2024 · GPX4 functions in concert with GSH to catalyze the reduction of hydrogen peroxide and organic hydroperoxides to water or the corresponding alcohols, which plays a vital role in protecting against ferroptosis [ 7, 8 ]. Direct inhibition of … mortality due to ncds
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated ... - PubMed
WebResults. CRC datasets and clinical samples analysis revealed that SPINK4 mRNA and protein levels were significantly reduced in CRC tissues compared to control tissues (P < 0.05).Two CRC cell lines (HCT116 and LoVo) were selected, and the in vitro and in vivo experiments showed that overexpression of SPINK4 greatly promotes the proliferation … WebDec 11, 2024 · GPX4 is a prognostic marker in human PDAC Our animal studies indicate that GPX4 may play a tumor suppressor-like role, whereas TMEM173 may have an oncogenic-like role in pancreatic... WebApr 10, 2024 · Moreover, high RUNX1-IT1 was linked to poor prognosis, and a strong positive correlation between RUNX1-IT1 and GPX4 was observed in clinical breast cancer tissues. Taken together, our data reveal that RUNX1-IT1 promotes breast cancer carcinogenesis through blocking ferroptosis via elevating GPX4, targeting of the … mortality during childbirth