Klf4 atherosclerosis
WebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many that regulate pro-inflammatory responses of SMCs. WebMar 29, 2024 · CSC increased the expression of inflammatory markers and reduced the contractile ones in both cell types, with KLF4 modulating the SMC phenotypic switch. Next, we performed a mass spectrometry-based differential proteomic approach on human SMCs and could show 11 proteins were significantly affected by exposition to CSC (FC ≥ 2.7, p ≤ …
Klf4 atherosclerosis
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WebAtherosclerosis, the leading cause of death, is a vascular disease of... WebIntroduction. Atherosclerosis is a disease of chronic inflammation and is the leading cause of morbidity and mortality worldwide. There is general consensus that the majority of coronary syndromes are the result of rupture of unstable plaques and associated thrombotic events 1-3.Plaque instability has been associated with disruption of the fibrous cap, an …
WebAtherosclerosis, the leading cause of death, is a vascular disease of... WebJun 4, 2015 · KLF4 is also a crucial factor for the generation of induced pluripotent stem cells 9. It has also recently been shown that loss of Klf4 in endothelial cells (ECs) or myeloid cells results in...
WebNov 19, 2012 · Here, we show that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis. Using in vivo EC-specific KLF4 overexpression and knockdown murine models, we found that KLF4 induced an antiadhesive, antithrombotic … WebKLF4 plays an important role in several vascular diseases where it was shown to regulate vascular inflammation by controlling macrophage polarization and plaque formation in atherosclerosis. It up-regulates Apolipoprotein E, which is an anti-atherosclerotic factor. It is also involved in the regulation of angiogenesis.
WebDec 1, 2014 · Blockade of mir-92a restores Klf2 and Klf4 expression, reduces endothelial inflammation and monocyte infiltration, thereby limiting atherosclerosis. 19 Disturbed flow and other proatherogenic factors also downregulate the endothelial expression of negative guidance cues, particularly Netrin-1 and Semaphorin3A, while upregulating EphrinB2, and …
WebJan 1, 2024 · These results indicate that formononetin may regulate KLF4 expression during atherosclerosis development. Given the role of KLF4 and SRA in atherogenesis, we postulate that formononetin may be antiatherogenic, in part, through regulation of KLF4-SRA … jcpenney formal wear dressesWebJul 1, 2024 · KLF4 is an important transcription factor of VSMCs phenotypic transformations, macrophage polarization, lymphocyte differentiation, and cell proliferation as atherosclerosis progression 29, 30,... lutheran pediatric associatesWebApr 21, 2024 · Laminar, but not disturbed flow, induces expression of the extracellular matrix protein TN-X (tenascin-X) in mouse and human endothelial cells through the transcription factor KLF4 (Krüppel-like factor … lutheran pediatric dentistWebMay 24, 2024 · The KLF4 gene is itself a CAD GWAS risk allele with the putative variant (rs944172) located ≈265 kb upstream of the KLF4 transcription start site. The nature of this variant is unclear; however, it overlaps a weak AP1 binding site with some evidence for … lutheran pediatric dentistryWebJan 11, 2024 · Notably, “Atherosclerosis Signaling” was the top pathway associated with the gene expression pattern in Klf4-deleted CD11b + myeloid cells isolated from Hi-Myc tumors. Atherosclerosis is a progressive disease that narrows the vascular lumen through a buildup of arterial plaque, an amalgam of lipids, macrophages and other leukocytes, smooth ... lutheran pediatric erWebDec 13, 2024 · KLF4 is a zinc-finger-containing transcription factor that plays a crucial role in maintaining cell senescence in response to cellular stress. Studies have shown that KLF4 typically upregulates p21 to promote cell growth arrest ( Chew et al., 2011 ). jcpenney former associate kiosk w2WebFeb 13, 2024 · KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015; 21:628–637. doi: 10.1038/nm.3866 Crossref Medline Google Scholar; 13. Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, … lutheran pediatric er fort wayne