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Maccannell fibroblast model

WebIt consists of a highly detailed 3D geometric model of the atria (754,893 nodes and 515,005 hexahedral elements with a homogeneous resolution of 300 μm) coupled to a torso model (254,976 nodes and 1.5 M tetrahedral elements) made up of lungs, bones, liver, ventricles, blood, and general torso, see Figure 1A. WebNational Center for Biotechnology Information

Frontiers Personalized Cardiac Computational Models: From Clinical ...

WebThe active models (Jacquemet & Henriquez, 2007; MacCannell et al., 2007) incorporate the discovery that cardiac fibroblasts express voltage-gated K+ currents (Chilton et al., 2005), while the passive models ... to the mammalian fibroblast model of Morgan et al.. A key advantage of the ‘attachment’ approach is that it can be easily employed ... property management waterville me https://luminousandemerald.com

Computational Approaches to Understanding the Role of Fibroblast ...

WebAug 23, 2016 · We patch-clamped guinea pig ventricular cardiomyocytes and used the dynamic-clamp technique to couple them to the MacCannell fibroblast electrophysiology model ( 27) via GJ channel models developed to represent the gating and kinetic properties of Cx43, Cx45, and Cx43/Cx45. Webical models of ventricular fibroblasts, a passive model (Xie et al., 2009b) and an active model (MacCannell et al., 2007), have been developed. However, to the best of our … WebMay 1, 2008 · contrast, MacCannell et al. (34) found using the same fibroblast model that ventricular action potentials were shortened by up to 100 ms when coupled to 4 fibroblasts with a conductance of 3 nS. property management wairoa

Fibroblast Electrical Remodeling in Heart Failure and Potential …

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Maccannell fibroblast model

Computational Approaches to Understanding the Role of …

WebMar 1, 2014 · In this study, the effects of cardiac fibroblast proliferation on cardiac electric excitation conduction and mechanical contraction were investigated using a proposed integrated myocardial-fibroblastic electromechanical model. At the cellular level, models of the human ventricular myocyte and fibroblast were modified to incorporate a model of … WebPubMed

Maccannell fibroblast model

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WebDownload scientific diagram Electrophysiological effects on the Courtemanche-Ramirez-Nattel myocytes when coupling to the active formulation of MacCannell fibroblast model. (A) shows the local ... WebMacCannell et al. used computational models of cell pairs using the Tusscher-Noble-Noble-Panfilov (TNNP) model of the human ventricular cardiomyocyte and their active …

WebDec 10, 2024 · Originating from the fibroblast model of MacCannell et al. (2007), the active model of Maleckar et al. (2009) includes the fibroblast membrane capacitance and four fibroblast ionic currents: time- and voltage-dependent fibroblast K + current (I KV), inward-rectifying K 1 + current (I K1) which is expressed in cardiac myofibroblasts, Na +-K ... WebJan 1, 2012 · Human atrial tissue model with regionally proliferated fibroblasts. A, Schematic representation of the Courte-manche human atrial myocyte model 16 connecting to the …

WebNov 18, 2014 · The total ionic current for the MacCannell fibroblast model (I ion,fb) is calculated as I ion, fb = I Kv, fb + I Kir, fb + I NaK, fb + I b, Na, fb − I gap where I Kv,fb and I Kir,fb are the fibroblast-delayed-rectifier and inward-rectifier K + currents, respectively, I NaK,fb is the Na + /K + exchange pump current, I b,Na,fb is the background Na … WebFeb 27, 2024 · We now find that when mixed with human breast cancer cells, each fibroblast subtype determines the fate of cancer cells: CD146- fibroblasts promoted …

WebAtrial Myocyte and Fibroblast Models The action potential was represented by the Courtemanche human atrial model.1 Each myocyte was electrically connected to a number of MacCannell model2 fibroblasts (Figure 1A). The fibroblast model2 includes time- and voltage-dependent K+ current (I Kv), inward-rectifying K+ current (I K1), Na +-K+ pump ...

WebNov 11, 2014 · The Ramirez-Nattel-Courtemanche (RNC) ionic model of canine atrial cardiomyocyte action potentials (APs) ( 25) was implemented and electrically connected to a variable number ( n) of MacCannell model fibroblasts ( 20) via gap junctions of conductance G gap. The total ionic current for the RNC model (I ion,RNC) is ladybug bathtub toy holderWebOct 25, 2015 · Simulations of F-M coupling pairs comparing coupling via dynamic Cx43, Cx45, and Cx43/Cx45 GJs to a static model. (a) Dynamic GJ models were used to couple the MacCannell fibroblast model to the ... property management walla wallaWebSimulations of F-M coupling pairs comparing coupling via dynamic Cx43, Cx45, and Cx43/Cx45 GJs to a static model. (a) Dynamic GJ models were used to couple the MacCannell fibroblast model to the modified Livshitz and Rudy model [] and compared it to the static model and an uncoupled cardiomyocyte model.From top to bottom: … ladybug background pngWebMay 1, 2008 · The electrophysiological properties of the fibroblasts were described by the MacCannell et al. ( 34) fibroblast model. This membrane kinetics model incorporates a time-dependent K + current formulated using two gating variables, an inward-rectifying K + current, an Na + -K + pump current, and a background Na + current. property management warsaw indianaWebFeb 16, 2007 · First, fibroblasts were modeled as a spherical cell with a capacitance of 6.3 pF and an ohmic membrane resistance of 10.7 GΩ. When these “passive” fibroblasts … ladybug beads st louisWebIonic channel currents of the atrial fibroblast model. (A–C) The simulated I-V curves for the major ionic currents (solid lines) are shown along with the respective experimental data … ladybug bakery hernando msWebIn the MacCannell model, four membrane ion currents are considered for fibroblasts: a time- and voltage-dependent “delayed-rectifier” K + current iKv, an inward-rectifying K + … property management waynesville mo