2024 Phenotypically modulated

Phenotypically modulated

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WebFeb 25, 2015 · In intimal lesions, we observed 2 phenotypically distinct subtypes of SMCs: hyperchromatic and oval cells staining positive for αSMA, vimentin, SM1 and HHF35 but … WebFeb 8, 2024 · Differentially expression analysis revealed that, compared to Rgs5 low SMCs, Rgs5 high SMCs expressed significantly higher levels of molecular signatures for phenotypically modulated SMCs as ...

KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role …

WebJan 13, 2013 · We identified large numbers of phenotypically modulated SMCs in lesions that showed no detectible expression of MYH11 ( Fig. 4c) or ACTA2 ( Fig. 4d) and were identifiable as being of SMC origin... WebFeb 25, 2015 · Assessment of phenotypically modulated smooth muscle cells SMCs in vascular lesions were immunophenotyped using two anti-SMC myosin heavy chain markers (SM1 and SM2) and three anti-actin markers (αSMA, HHF35, and CGA7). change kindle location setting

Coronary Artery Disease Risk Gene - biorxiv.org

WebMay 23, 2024 · Methods: To perform an unbiased and systematic analysis of the molecular regulatory mechanism of phenotypic switching of SMCs during AS in mice, we searched … WebPhenotypic modulation refers to the unique ability of SMCs to alter their phenotype in response to extracellular stimuli and is hallmarked by the loss of SMC m … Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle Am J Physiol Heart Circ Physiol. WebVICs express number of VSMC-specific proteins and display features of phenotypically modulated VSMCs with increased migratory abilities. VICs, therefore represent resident … change kindle paperwhite background

Single-cell RNA sequencing identifies an - Nature

Modulation of Smooth Muscle Cell Phenotype

WebJan 1, 2024 · Phenotypic modulation Methods We summarize findings from extensive literature searches to highlight recent discoveries in the mechanisms underlying vascular smooth muscle cell (VSMC) phenotypic switching with particular relevance to intimal hyperplasia. PubMed was searched from January 2001 to December 2024. WebApr 25, 2024 · During aneurysm formation, smooth muscle cells undergo a process known as phenotypic modulation. Although this process has been well-studied, the possible role … change kindle fire search barWebOct 22, 2024 · To determine whether the dysfunction of the LXRα-ABCA1 axis is common in phenotypically modulated VSMCs, we performed the proteomic analysis of the contractile and synthetic VSMCs and showed that... hardship home

"WebJun 26, 2008 · Animal Model KLF5 is a transcription factor for Smemb/nonmuscle myosin heavy chain B, which is a molecular marker of phenotypically modulated smooth muscle cells. Normally, KLF5 is abundantly expressed in developing blood vessels, but is downregulated in adult vessels. " - Phenotypically modulated

Phenotypically modulated

WebOct 7, 2024 · To form the FC, SMC undergo phenotypic modulation in response to atherogenic stimuli and migrate from the media into atherosclerotic lesions. 5–7 Recent lineage tracing studies in mice revealed that SMC can be beneficial or detrimental in atherosclerotic lesions, depending on the specific SMC phenotypic transitions. 7–13 For … WebFeb 11, 2024 · Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female versus male plaques is unknown. Here, we show sex-stratified gene regulatory networks (GRNs) from human carotid atherosclerotic tissue.

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WebFeb 11, 2024 · Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female … WebSep 15, 2024 · these SMC progenies have been previously lumped together as phenotypically modulated SMC, advances in single cell RNA profiling has demonstrated the presence of subsets of these cells with distinct transcriptomes and cell fates. For example, medial SMC have been shown to give

WebDec 21, 2012 · Although the majority of studies of the phenotypic modulation of VSMCs has focused on the remodelling of blood vessels during disease or injury, little is known about … WebJun 1, 2012 · Phenotypically modulated SMCs are characterized by a decreased expression of SMC-specific proteins and show a high degree of proliferation and the ability to …

WebAug 1, 2024 · In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of...

WebAug 31, 2012 · Previous studies have shown that SMC phenotype is actively regulated via transduction of growth factor-mediated and biomechanical signals to the nucleus …

WebJan 23, 2009 · An accumulation of these phenotypically modulated SMCs within the diseased vessel contributes to plaque formation and the consequent narrowing of the vascular lumen. Our laboratory has had a long-standing interest in unraveling the molecular mechanisms that contribute to the phenotypic modulation of SMCs to prevent or reduce … change kindle paperwhite wallpaperWebApr 15, 2014 · Studies within this dissertation are focused on identifying phenotypically modulated SMCs within atherosclerotic lesions using a newly developed conditional SMC specific lineage tracing mouse model, and a novel method that allows for the visualization of histone modifications of single genomic loci with single-cell resolution in formaldehyde ... hardship help with billsWebMay 18, 2015 · Shown are phenotypically modulated SMCs (YFP + ACTA2 − cells highlighted in the white rectangle, b ), macrophage-like SMCs (YFP + ACTA2 − LGALS3 +, … hardship home equity loansWebThis increase in the number of phenotypically modulated perivascular cells was specific to pre-metastatic lung tissue, in that a similar expansion of perivascular cells was not seen in other... change kindle fire color settingsWebNov 11, 2024 · In-depth single-cell RNA sequencing demonstrates that SMC-Has3 deletion driven expansion of phenotypically modulated SMC drives increases in acute-phase response gene expression. Blocking the important HA binding receptor, cluster of differentiation-44 (CD44), recapitulates the enhanced acute-phase response and … hardship hubWebNational Center for Biotechnology Information hardship housingWe tested the hypothesis that phenotypically modulated smooth … hardship home loan modifications